n.BA.BT.TiEn.22.HS (Tissue Engineering) 
Module: Tissue Engineering
This information was generated on: 01 October 2022
No.
n.BA.BT.TiEn.22.HS
Title
Tissue Engineering
Credits
2

Description

Version: 1.0 start 01 August 2022

 

Study Programme Biotechnology
Regulations Applicable RPO, 29 January 2008, School of Life Sciences and Facility Management Academic Regulations, 15 Dec. 2009, Annex for the Bachelor of Biotechnology degree programme
Module Type  
X Compulsory Module    Elective Module    Optional Module
Planned Semester 4th Smester
Module Coordinator Michael Raghunath
Telephone / E-Mail +41 (0)58 934 55 18 / michael.raghunath@zhaw.ch
Lecturer(s),
Speaker(s),
Associate(s)
Michael Raghunath, Markus Rimann
Entrance Requirements Cell Biology 1 and Cell Culture Techniques 1, Biochemistry 2
Learning Outcomes and Competencies Students will
  • be able to describe and explain the basic principles of tissue engineering and which components are needed for this.
  • be able to describe how tissue is formed and, based on this, explain which challenges exist in vitro.
  • know different biomaterials that can be used for tissue engineering and be able to describe advantages and disadvantages of these materials.
  • be able to compare the advantages and disadvantages of different stem cell types and sources for tissue engineering.
  • be able to critically evaluate tissue engineering reports published in the media and in the specialised press with regard to scalable industrial and clinical applicability.
Module Content Introduction:
  • State of the art and industrialisation of tissue engineering (TE), From cell to tissue.
 
Block 1: Cells and cell sources
  • Stem cells and derivation, and generation (IPSC, HES, differentiated cells), embryological features
 
Block 2: Cells and their regulators, manipulation
  • ECM and ligands
  • Mechanobiology: cytoskeleton and ECM signalling
  • Influence of culture conditions (e.g. MMC) on cell behaviour
  • Shear forces, cyclic loading, dynamic culture systems, growth factors (gradients), stem cell differentiation
 
Block 3: Scaffolding for TE
  • Polymers for TE (biodegradable, non-degradable)
  • Naturally-occurring scaffolding materials and MMC invitro
  • Organ tissue engineering (decell/recell)
  • Bioprinting, cell sheet
 
Block 4: Reality check and emerging tech
  • Current constraints (implant: angiogenesis, 3D, hypoxia)
  • Clinically successful TE products
  • Diagnostically successful and important strategies (spheroids and organoids, (liver, pancreas, tumours), transwell models (TEER, cocultures, immune populations)
  • Invivo TE (body as bioreactor, example of bone substitute, implantable lymph node)
Follow-up Modules Molecular Biology 3 and Immunology 2 lecture and practical, Cell Biology 2 and Tissue Engineering practical, Cell and Tissue Therapy Minor, Pharmaceutical Technology Minor
Methods of Instruction  Lectures and set tasks
Digital Resources Video resources
Lesson Structure / Workload  
 Contact Hours 20
 Guided Self-Study 8
 Independent Self-Study 32
 Total Workload 60
Classroom Attendance No
Assessment
Written exam at the end of the semester 100%
 
If there is a low number of participants, the lecturer may change the form of a repeat examination after consultation with the head of the study programme: e.g. an oral examination can be used to replace a written one. Please report any changes to the form of examinations by e-mail to pruefungsadmin.lsfm@zhaw.ch and Cc. Head of study programme.
Language of Instruction  German
Comments Selected further reading:

Robert Lanza, Robert Langer, Joseph P. Vacanti, Anthony Atala, Principles of Tissue Engineering, 5th edition,
Academic Press, 1678 Seiten (Englisch)
 
Alberts et al, Lehrbuch der Molekularen Zellbiologie, Wiley-VCH
 
Lodish et al, Molecular Cell Biology, W.H. Freeman

 

Course: Tissue Engineering
No.
n.BA.BT.TiEn.22.HS.V
Title
Tissue Engineering

Note

  • No module description is available in the system for the cut-off date of 01 October 2022.