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n.BA.BT.TiEn.22.HS (Tissue Engineering)
Module: Tissue Engineering
This information was generated on: 12 February 2025
No.
n.BA.BT.TiEn.22.HS
Title
Tissue Engineering
Credits
2
Description
Version: 2.0 start 01 August 2022
Study Programme
Biotechnology
Regulations Applicable
RPO, 29 January 2008, School of Life Sciences and Facility Management Academic Regulations, 15 Dec. 2009, Annex for the Bachelor of Biotechnology degree programme
Module Type
X
Compulsory Module
Elective Module
Optional Module
Planned Semester
4th Smester
Module Coordinator
Markus Rimann
Telephone / E-Mail
+41 (0)58 934 55 12 /
markus.rimann@zhaw.ch
Lecturer(s),
Speaker(s),
Associate(s)
Markus Rimann und various lecturers
Entrance Requirements
Cell Biology 1 and Cell Culture Techniques 1, Biochemistry 2
Learning Outcomes and Competencies
Students will
be able to describe and explain the basic principles of tissue engineering and which components are needed for this.
be able to describe how tissue is formed and, based on this, explain which challenges exist in vitro.
know different biomaterials that can be used for tissue engineering and be able to describe advantages and disadvantages of these materials.
be able to compare the advantages and disadvantages of different stem cell types and sources for tissue engineering.
be able to critically evaluate tissue engineering reports published in the media and in the specialised press with regard to scalable industrial and clinical applicability.
Module Content
Introduction:
State of the art and industrialisation of tissue engineering (TE), From cell to tissue.
Block 1: Cells and cell sources
Stem cells and derivation, and generation (IPSC, HES, differentiated cells), embryological features
Block 2: Cells and their regulators, manipulation
ECM and ligands
Mechanobiology: cytoskeleton and ECM signalling
Influence of culture conditions (e.g. MMC) on cell behaviour
Shear forces, cyclic loading, dynamic culture systems, growth factors (gradients), stem cell differentiation
Block 3: Scaffolding for TE
Polymers for TE (biodegradable, non-degradable)
Naturally
-
occurring scaffolding materials and MMC invitro
Organ tissue engineering (decell/recell)
Bioprinting, cell sheet
Block 4: Reality check and emerging tech
Current constraints (implant: angiogenesis, 3D, hypoxia)
Clinically successful TE products
Diagnostically successful and important strategies (spheroids and organoids, (liver, pancreas, tumours), transwell models (TEER, cocultures, immune populations)
Invivo TE (body as bioreactor, example of bone substitute, implantable lymph node)
Follow-up Modules
Molecular Biology 3 and Immunology 2 lecture and practical, Cell Biology 2 and Tissue Engineering practical, Cell and Tissue Therapy Minor, Pharmaceutical Technology Minor
Methods of Instruction
Lectures and set tasks
Digital Resources
Video resources
Lesson Structure / Workload
Contact Hours
20
Guided Self-Study
8
Independent Self-Study
32
Total Workload
60
Classroom Attendance
No
Assessment
Written exam at the end of the semester 100%
If there is a low number of participants, the lecturer may change the form of a repeat examination after consultation with the head of the study programme: e.g. an oral examination can be used to replace a written one. Please report any changes to the form of examinations by e-mail to
pruefungsadmin.lsfm@zhaw.ch
and Cc. Head of study programme.
Language of Instruction
German
Comments
Selected further reading:
Robert Lanza, Robert Langer, Joseph P. Vacanti, Anthony Atala, Principles of Tissue Engineering, 5th edition,
Academic Press, 1678 Seiten (Englisch)
Alberts et al, Lehrbuch der Molekularen Zellbiologie, Wiley-VCH
Lodish et al, Molecular Cell Biology, W.H. Freeman
Course: Tissue Engineering
No.
n.BA.BT.TiEn.22.HS.V
Title
Tissue Engineering
Note
No module description is available in the system for the cut-off date of 12 February 2025.