n.BA.BT.ZB2.22HS (Cellular Biology 2) 
Module: Cellular Biology 2
This information was generated on: 29 March 2024
No.
n.BA.BT.ZB2.22HS
Title
Cellular Biology 2
Credits
2

Description

Version: 1.0 start 01 August 2022

 

Study Programme Biotechnology
Regulations Applicable RPO, 29 January 2008, School of Life Sciences and Facility Management Academic Regulations, 15 Dec. 2009, Annex for the Bachelor of Biotechnology degree programme
Module Type  
X Compulsory Module    Elective Module    Optional Module
Planned Semester 4th Semester
Module Coordinator Jack Rohrer
Telephone / E-Mail +41 (0)58 934 57 17 / jack.rohrer@zhaw.ch
Lecturer(s),
Speaker(s),
Associate(s)
-
Entrance Requirements Cell Biology 1 and Cell Culture Technology 1, Cell Biology and Cell Culture Technology 1 practical, Pharmacology
Learning Outcomes and Competencies Students will deepen their knowledge of of cell biology fundamentals and will be able to:
  • explain the principles of protein sorting in detail using examples, and determine the different transport pathways of proteins in the cell by analysing signal sequences.
  • design a schematic diagram with the components of the cellular machinery required to secrete proteins.
  • analyse the signal transduction pathways of GPCRs and their effects.
  • analyse the causes of certain types of cancer and assign specific factors of these to the regulation of the cell cycle and/or apoptosis.
  • name the different types of stem cells and their properties, and explain the generation and applications of induced pluripotent stem cells (iPSCs).
  • explain the cellular basis of selected physiological processes in humans (regulation of respiration and blood pressure).
Module Content Cell biology focuses on understanding how mammalian cells behave individually and as a part of composite systems (organs). First of all, the basics of Cell Biology 1 and Cell Culture Technology 1 are expanded upon: the significance of important synthesis and transport pathways and their application in practice, as well as the molecular regulation of the cell cycle. Building on this, examples of complex mechanisms of human physiology and the development of diseases such as cancer are explained, as well as different treatments thereof.
 
Block 1: Protein targeting
  • Molecular mechanisms of protein sorting
  • Secretory vs endocytotic pathway
  • The role of protein sorting in the commercial production of proteins
  • Diseases caused by errors in protein sorting (exercises set against the background of e.g. Cystic Fibrosis, Muccolipidosis II, Familial Hypercholesterolemia) and their treatment.
 
Block 2: Receptors, signal transduction and their importance for medicine.
  • Overview/details of GPCRs, ligands and signal transduction pathways
  • Specific examples
  • 1-adrenergic receptor - heart rate
  • Opsin/Rhodopsin - vision
  • Chemokine receptors
  • Opioid receptors
 
Block 3: Cell cycle, apoptosis and cancer
  • Molecular regulation of the cell cycle
  • Molecular regulation of apoptosis
  • Development and spread (metastasis) of cancer
  • Classic treatment of cancer
  • Cell-based methods for the treatment of cancer
 
Block 4: Overview stem cell biology
  • Properties of stem cells
  • Production of induced pluripotent stem cells (iPSCs)
  • Applications of iPSCs with examples of differentiation, practical examples of differentiation (keratinocytes, myoblasts, cardiomyocytes, BMECs
  • Analysis/assessment of differentiation (quality control)
 
Block 5: Physiology
  • Regulation of blood pressure
  • Regulation of respiration
Follow-up Modules Molecular Biology 3 and Immunology 2, Minor
Methods of Instruction  Lectures and assigned tasks
Digital Resources Video resources
Lesson Structure / Workload  
 Contact Hours 20
 Guided Self-Study 8
 Independent Self-Study 32
 Total Workload 60
Classroom Attendance No
Assessment
Written exam at the end of the semester 100%
 
If there is a low number of participants, the lecturer may change the form of a repeat examination after consultation with the head of the study programme: e.g. an oral examination can be used to replace a written one. Please report any changes to the form of examinations by e-mail to pruefungsadmin.lsfm@zhaw.ch and Cc. Head of study programme.
Language of Instruction  German
Comments Teaching materials:
‘Fundamentals of Cell Biology’ slides and ‘Fundamentals of Cell Culture Technology’ slides.

Selection of further reading:
Alberts et al, Textbook of Molecular Cell Biology, Wiley-VCH.

Lodish et al, Molecular Cell Biology, W.H. Freeman

Cooper and Hausman, The Cells: A Molecular Approach, ASM Press and Sinauer Associates

 

Course: Cellular Biology 2
No.
n.BA.BT.ZB2.22HS.V
Title
Cellular Biology 2

Note

  • No module description is available in the system for the cut-off date of 29 March 2024.