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n.BA.BT.ZB2.22HS (Cellular Biology 2)
Module: Cellular Biology 2
This information was generated on: 29 March 2024
No.
n.BA.BT.ZB2.22HS
Title
Cellular Biology 2
Credits
2
Description
Version: 1.0 start 01 August 2022
Study Programme
Biotechnology
Regulations Applicable
RPO, 29 January 2008, School of Life Sciences and Facility Management Academic Regulations, 15 Dec. 2009, Annex for the Bachelor of Biotechnology degree programme
Module Type
X
Compulsory Module
Elective Module
Optional Module
Planned Semester
4th Semester
Module Coordinator
Jack Rohrer
Telephone / E-Mail
+41 (0)58 934 57 17 /
jack.rohrer@zhaw.ch
Lecturer(s),
Speaker(s),
Associate(s)
-
Entrance Requirements
Cell Biology 1 and Cell Culture Technology 1, Cell Biology and Cell Culture Technology 1 practical, Pharmacology
Learning Outcomes and Competencies
Students will deepen their knowledge of of cell biology fundamentals and will be able to:
explain the principles of protein sorting in detail using examples
,
and determine the different transport pathways of proteins in the cell by analysing signal sequences.
design a schematic diagram with the components of the cellular machinery required to secrete proteins.
analyse the signal transduction pathways of GPCRs and their effects.
analyse the causes of certain types of cancer and assign specific factors of these to the regulation of the cell cycle and/or apoptosis.
name the different types of stem cells and their properties, and explain the generation and applications of induced pluripotent stem cells (iPSCs).
explain the cellular basis of selected physiological processes in humans (regulation of respiration and blood pressure).
Module Content
Cell biology focuses on understanding how mammalian cells behave individually and as a part of composite systems (organs). First of all, the basics of Cell Biology 1 and Cell Culture Technology 1 are expanded upon: the significance of important synthesis and transport pathways and their application in practice, as well as the molecular regulation of the cell cycle. Building on this, examples of complex mechanisms of human physiology and the development of diseases such as cancer are explained, as well as different treatments thereof.
Block 1: Protein targeting
Molecular mechanisms of protein sorting
Secretory vs endocytotic pathway
The role of protein sorting in the commercial production of proteins
Diseases caused by errors in protein sorting (exercises set against the background of e.g. Cystic Fibrosis, Muccolipidosis II, Familial Hypercholesterolemia) and their treatment.
Block 2: Receptors, signal transduction and their importance for medicine.
Overview/details of GPCRs, ligands and signal transduction pathways
Specific examples
1-adrenergic receptor - heart rate
Opsin/Rhodopsin - vision
Chemokine receptors
Opioid receptors
Block 3: Cell cycle, apoptosis and cancer
Molecular regulation of the cell cycle
Molecular regulation of apoptosis
Development and spread (metastasis) of cancer
Classic treatment of cancer
Cell-based methods for the treatment of cancer
Block 4: Overview stem cell biology
Properties of stem cells
Production of induced pluripotent stem cells (iPSCs)
Applications of iPSCs with examples of differentiation, practical examples of differentiation (keratinocytes, myoblasts, cardiomyocytes, BMECs
Analysis/assessment of differentiation (quality control)
Block 5: Physiology
Regulation of blood pressure
Regulation of respiration
Follow-up Modules
Molecular Biology 3 and Immunology 2, Minor
Methods of Instruction
Lectures and assigned tasks
Digital Resources
Video resources
Lesson Structure / Workload
Contact Hours
20
Guided Self-Study
8
Independent Self-Study
32
Total Workload
60
Classroom Attendance
No
Assessment
Written exam at the end of the semester 100%
If there is a low number of participants, the lecturer may change the form of a repeat examination after consultation with the head of the study programme: e.g. an oral examination can be used to replace a written one. Please report any changes to the form of examinations by e-mail to
pruefungsadmin.lsfm@zhaw.ch
and Cc. Head of study programme.
Language of Instruction
German
Comments
Teaching materials:
‘Fundamentals of Cell Biology’ slides and ‘Fundamentals of Cell Culture Technology’ slides.
Selection of further reading:
Alberts et al, Textbook of Molecular Cell Biology, Wiley-VCH.
Lodish et al, Molecular Cell Biology, W.H. Freeman
Cooper and Hausman, The Cells: A Molecular Approach, ASM Press and Sinauer Associates
Course: Cellular Biology 2
No.
n.BA.BT.ZB2.22HS.V
Title
Cellular Biology 2
Note
No module description is available in the system for the cut-off date of 29 March 2024.