n.BA.XX.MZGEHZ.23HS (Development and Production of Cell Therapeutics) 
Module: Development and Production of Cell Therapeutics
This information was generated on: 16 May 2024
No.
n.BA.XX.MZGEHZ.23HS
Title
Development and Production of Cell Therapeutics
Credits
2

Description

Version: 2.0 start 01 August 2023

 

Study Programme Biotechnology / Chemistry
Regulations Applicable RPO, 29 January 2008, School of Life Sciences and Facility Management Academic Regulations, 15 Dec. 2009, Annex for the Bachelor of Biotechnology degree programme

RPO, 29 January 2008, School of Life Sciences and Facility Management Academic Regulations, 15 Dec. 2009, Annex for the Bachelor of Chemistry degree programme
Module Type  
X Compulsory Module    Elective Module    Optional Module
Planned Semester 5th Semester
Module Coordinator Prof. Dr. Regine Eibl
Telephone / E-Mail +41 (0)58 934 57 13 / regine.eibl@zhaw.ch
Lecturer(s),
Speaker(s),
Associate(s)		 Prof. Dr. Regine Eibl, Prof. Dr. Jack Rohrer
Entrance Requirements Cell Biology 1, Cell Culture Techniques 1
Learning Outcomes and Competencies The lecture series aims to provide participants with the fundamentals for developing and producing cell therapeutics using relevant stem cells.
Module Content
  • ​Introduction to the minor 
  • Isolation and generation of relevant stem cell types
    • iPSCs (induced pluripotent stem cells)
    • hMSCs (human mesenchymal stem cells)
    • NCSCs (neural crest stem cells)
  • Hematopoietic cells • Production of hMSC and hiPSC-based cell therapeutics
    • Commercial products
    • Cell processing workflow
    • Culture media and microcarriers
    • Spheroid cultures
    • Bioreactors
    • Repeated fed-batch vs. perfusion
    • Scale-up approaches
    • Downstream processing challenges
Follow-up Modules None
Methods of Instruction  Lectures, practice exercises, pop quizzes
Digital Resources Videos
Lesson Structure / Workload  
 Contact Hours 30
 Guided Self-Study 10
 Independent Self-Study 20
 Total Workload 60
Classroom Attendance Keine
Assessment Written exam at the end of the semester  100%

For small groups, a separate module examination may also be conducted orally.

If there is a low number of participants, the lecturer may change the form of a repeat examination after consultation with the head of the study programme: e.g. an oral examination can be used to replace a written one. Please report any changes to the form of examinations by e-mail to pruefungsadmin.lsfm@zhaw.ch and Cc. Head of study programme.
Language of Instruction  German
Comments The Development and Production of Cell Therapeutics module is part of the Minor Cell and Tissue Therapy module group. 

Bibliography

Lecture slides 

M. Teale, V. Jossen, D. Eibl, R. Eibl (2022) Chemically defined, xeno-free expansion of human mesenchymal stem cells (hMSCs) on benchtop-scale using a stirred single-use bioreactor. In: Bioreactors in stem cell biology. K. Turksen (ed.), Humana Press, 83-111. DOI 10.1007/7651_2021_426

V. Jossen, F. Muoio, S. Panella, Y. Harder, T. Tallone, R. Eibl (2020) An approach towards a GMP compliant in vitro expansion of human adipose stem cells for autologous therapies. Bioengineering. DOI:10.3390/bioenginerering703077

C. van den Bos, V. Jossen, D. Eibl, R. Eibl (2019) Advanced therapy medicinal products (ATMPs) & GMP – 10 years after. Pharmaceutical Industry 81(4): 508-513

V. Jossen, R. Eibl, C. van den Bos, D. Eibl (2018) Manufacturing human mesenchymal stem cells at clinical scale: Process and regulatory challenges. Applied Microbiology and Biotechnology. doi.org/10.1007/s00253-018-8912-x

 

Course: Development and Production of Cell Therapeutics
No.
n.BA.XX.MZGEHZ.23HS.V
Title
Development and Production of Cell Therapeutics

Note

  • No module description is available in the system for the cut-off date of 16 May 2024.